Nature Search

Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis

Schneeberger, Kim, Geesdorf, Rajewsky, Heppner et al. tease IL-12 and IL-23 signaling apart in mouse models and human brain tissue to define a role for oligodendroglial and neuronal IL-12 signaling in neuroimmune crosstalk in Alzheimer’s disease.

Shirin Schneeberger
Seung Joon Kim
Frank L. Heppner
ResearchOpen Access13 Mar 2025
Nature Aging

Volume: 5, P: 622-641
A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52

Kathrin Hacker
Stefan Benke
Gijs A. Versteeg
ResearchOpen Access27 May 2019
Scientific Reports

Volume: 9, P: 1-9
Post-translational coordination of chlorophyll biosynthesis and breakdown by BCMs maintains chlorophyll homeostasis during leaf development

Plants regulate chlorophyll levels to optimise photosynthesis. Here Wang et al. describe two paralogous thylakoid proteins, BCM1 and BCM2, which stimulate chlorophyll biosynthesis and attenuate chlorophyll degradation respectively through interaction with the Mg-chelatase-stimulating factor GUN4 and Mg-dechelatase isoform SGR1.

Peng Wang
Andreas S. Richter
Bernhard Grimm
ResearchOpen Access20 Mar 2020
Nature Communications

Volume: 11, P: 1-17
Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

H Rob Taal
Beate St Pourcain
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume

M Arfan Ikram
Myriam Fornage
James F Wilson
Amendments and Corrections29 May 2013
Nature Genetics

Volume: 45, P: 713
Common variants at 12q15 and 12q24 are associated with infant head circumference

Vincent Jaddoe and colleagues report a genome-wide association study for infant head circumference. They identify variants in SBNO1 and near HMGA2 that are associated with this phenotype.

H Rob Taal
Beate St Pourcain
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 532-538
Next generation automated traceless cell chromatography platform for GMP-compliant cell isolation and activation

Sabine Radisch
Mateusz P. Poltorak
Lothar Germeroth
ResearchOpen Access21 Apr 2022
Scientific Reports

Volume: 12, P: 1-13
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram and colleagues report a genome-wide association study for intracranial volume and brain volume. They report two loci associated with intracranial volume.

M Arfan Ikram
Myriam Fornage
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 539-544

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