Nature Search

A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation

Centrosome dynamics play a central role in immune regulation. Here, the authors demonstrate that centrosome integrity as well as centriole numbers and spatial organisation emerge as critical determinants of effective T cell responses.

Isabel Stötzel
Ann-Kathrin Weier
Eva Kiermaier
ResearchOpen Access13 Jan 2026
Nature Communications

Volume: 17, P: 1-24
Role of microRNAs in wasting in heart failure

Stephan von Haehling
Nicole Ebner
Stefan D. Anker
Correspondence03 Aug 2017
Nature Reviews Cardiology

Volume: 14, P: 566
DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours

Jan Mollenhauer
Stefan Wiemann
Annemarie Poustka
Research01 Sept 1997
Nature Genetics

Volume: 17, P: 32-39
Tetrahydrobiopterin enhances regulatory T- and mast cell proliferation and alters cytokines expression in a murine heart transplant model

Susanne Ebner
Bernhard Texler
Manuel Maglione
ResearchOpen Access16 Oct 2025
Scientific Reports

Volume: 15, P: 1-15
Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation

“In-depth cell-selective proteomics and secretomics has remained challenging. Here, the authors devise an optimised azidonorleucine labelling, mass spectrometry method and detect over 10,000 proteins in a pancreatic ductal adenocarcinoma model.

Jonathan J. Swietlik
Stefanie Bärthel
Felix Meissner
ResearchOpen Access08 May 2023
Nature Communications

Volume: 14, P: 1-17
Influence of circadian clocks on adaptive immunity and vaccination responses

Circadian rhythms have been shown to influence immune responses, but it is unclear whether this influences responses to vaccines. Here the authors show that dendritic cells migrate in a circadian rhythm meaning that interactions with T cells are altered leading to differential vaccine responses.

Louise Madeleine Ince
Coline Barnoud
Christoph Scheiermann
ResearchOpen Access30 Jan 2023
Nature Communications

Volume: 14, P: 1-13
Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns

An atomic force microscope can measure the distances between 5-methylcytidine bases in individual DNA strands with a resolution of 4 Å, which should prove useful in studies of gene expression.

Rong Zhu
Stefan Howorka
Peter Hinterdorfer
Research31 Oct 2010
Nature Nanotechnology

Volume: 5, P: 788-791
Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver

Normothermic machine perfusion (NMP) is a method of keeping transplant organs maintained closer to physiological conditions. Here the authors analyse the immune cell dynamics during NMP in human donor livers using scRNA sequencing as a way of assessing the effects of NMP upon the immune status of the organ.

T. Hautz
S. Salcher
S. Schneeberger
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-18
A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

Shelley Potter
Kerry Avery
Anagha Zope
ResearchOpen Access28 Oct 2025
npj Breast Cancer

Volume: 11, P: 1-10
Muscle wasting and cachexia in heart failure: mechanisms and therapies

Muscle wasting (sarcopenia) and loss of weight (cachexia) can occur in patients with heart failure. In this Review, von Haehling and colleagues provide an overview of the prevalence and pathophysiological mechanisms of these processes in heart failure, and discuss potential therapeutic strategies, including exercise training, nutritional supplements, and drug treatments.

Stephan von Haehling
Nicole Ebner
Stefan D. Anker
Reviews24 Apr 2017
Nature Reviews Cardiology

Volume: 14, P: 323-341
Ferritin in glioblastoma

Heidi Jaksch-Bogensperger
Sabine Spiegl-Kreinecker
Nikolaus Bresgen
ResearchOpen Access23 Mar 2020
British Journal of Cancer

Volume: 122, P: 1441-1444
Proteomic profiling of the weed feverfew, a neglected pollen allergen source

Isabel Pablos
Stephanie Eichhorn
Gabriele Gadermaier
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

Michael Lukas
Iulia Toth
Inga D Neumann
Research15 Jun 2011
Neuropsychopharmacology

Volume: 36, P: 2159-2168
The role of Smad signaling in hematopoiesis

Jonas Larsson
Stefan Karlsson
Reviews29 Aug 2005
Oncogene

Volume: 24, P: 5676-5692
Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence

A convolutional neural network (U-Net) for the assessment of aberrant CTLA-4 antibody staining using two independent antibody clones (MSVA-152R and CAL49) was trained and validated on 4582 tumor samples in this study. The deep learning-based framework facilitated automated CTLA-4 quantification in more than 90 different tumor entities via compensating for individual antibody shortcomings.

David Dum
Tjark L. C. Henke
Niclas C. Blessin
ResearchOpen Access29 Jan 2022
Laboratory Investigation

Volume: 102, P: 650-657

Search

A centrally positioned cluster of multiple centrioles in antigen-presenting cells fosters T cell activation

Role of microRNAs in wasting in heart failure

DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours

Tetrahydrobiopterin enhances regulatory T- and mast cell proliferation and alters cytokines expression in a murine heart transplant model

Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation

Influence of circadian clocks on adaptive immunity and vaccination responses

Nanomechanical recognition measurements of individual DNA molecules reveal epigenetic methylation patterns

Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver

A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials

Muscle wasting and cachexia in heart failure: mechanisms and therapies

Ferritin in glioblastoma

Proteomic profiling of the weed feverfew, a neglected pollen allergen source

The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice

The role of Smad signaling in hematopoiesis

Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence

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