Heidenreich et al. show that KCNQ4—a gene encoding a K+ channel whose mutation is linked to progressive human deafness—is expressed in a subset of dorsal root ganglion neurons and mechanosensory touch neurons that serve tactile sensation. The authors show that KCNQ4 loss of function in mice causes a specific tactile dysfunction owing to altered touch sensitivity. The study also finds that human subjects with KCNQ4 mutations and progressive deafness are hypersensitive to tactile information and are able to discern minute high-frequency tactile vibrations.
- Matthias Heidenreich
- Stefan G Lechner
- Gary R Lewin
