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Alternative meiotic chromatid segregation in the holocentric plant Luzula elegans

Conventionally, meiosis depends on a two-step loss of chromosome cohesion that requires distinction between chromosome arms and sister centromeres. Heckmann et al.show that a plant that lacks a single defined centromere overcomes this problem by inverting the sequence of meiotic segregation events.

Stefan Heckmann
Maja Jankowska
Andreas Houben
ResearchOpen Access08 Oct 2014
Nature Communications

Volume: 5, P: 1-10
Predicting enzyme turnover rates

Jan-Stefan Völler
Research Highlights14 Jan 2019
Nature Catalysis

Volume: 2, P: 6
Diversity favoured: heterozygosity attracts crossovers

The juxtaposition effect increases meiotic crossover frequency in heterozygous chromosome regions flanked by homozygous regions. Initially discovered in self-fertilizing Arabidopsis, this mechanism also operates in the outcrossing cereal crop maize.

Maria Cuacos
Stefan Heckmann
News & Views02 Sept 2025
Nature Plants

Volume: 11, P: 1706-1707
The synaptonemal complex central element SCEP3 interlinks synapsis initiation and crossover formation in Arabidopsis thaliana

This study identifies SCEP3 as a conserved central element of the plant synaptonemal complex. SCEP3 is critical for synapsis, heterochiasmy and crossover interference. SCEP3 also promotes a subset of crossover events.

Chao Feng
Jana Lorenz
Stefan Heckmann
ResearchOpen Access27 Jun 2025
Nature Plants

Volume: 11, P: 1353-1366
A haplotype-resolved pangenome of the barley wild relative Hordeum bulbosum

A study describes the assembly and analysis of a haplotype-resolved pangenome of bulbous barley with the potential to improve domesticated barley and illustrates its use in evolutionary research and trait mapping.

Jia-Wu Feng
Hélène Pidon
Martin Mascher
ResearchOpen Access09 Jul 2025
Nature

Volume: 645, P: 429-438
TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana

TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis enables identification of proximate proteins in rare cell types such as meiotic cells. Among 39 ASY1 and/or ASY3 proximate proteins known and new meiotic proteins were found.

Chao Feng
Elisabeth Roitinger
Stefan Heckmann
Research13 Mar 2023
Nature Plants

Volume: 9, P: 616-630
High level expression of glucocorticoid receptor (GR) is linked to aggressive tumor features, early biochemical recurrence, and genetic instability in prostate cancer

Neele Heckmann
Henning Plage
Sarah Weinberger
ResearchOpen Access05 Nov 2025
Prostate Cancer and Prostatic Diseases

P: 1-8
Changing local recombination patterns in Arabidopsis by CRISPR/Cas mediated chromosome engineering

The heterochromatic knob (hk4S) on Arabidopsis chromosome 4 prevents the recombination between accessions with and without hk4S. Here, via egg-cell specific expression of the Cas9 nuclease, the authors demonstrate targeted reversal of the 1.1 Mb long hk4S-inversion in Col-0 and restore the crossovers with Ler-1.

Carla Schmidt
Paul Fransz
Holger Puchta
ResearchOpen Access04 Sept 2020
Nature Communications

Volume: 11, P: 1-8
Activity-dependent site-specific changes of glutamate receptor composition in vivo

Andreas Schmid
Stefan Hallermann
Stephan J Sigrist
Research11 May 2008
Nature Neuroscience

Volume: 11, P: 659-666
Assessing Cortisol Production in Preterm Infants: Do Not Dispose of the Nappies

Matthias Heckmann
Michaela F Hartmann
Stefan A Wudy
Research01 Mar 2005
Pediatric Research

Volume: 57, P: 412-418
Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states

Complex molecular interactions occur in the active zone cytomatrix (CAZ) within the presynaptic terminal to regulate synaptic plasticity. Here, the authors use imaging techniques to show that the CAZ is composed of units containing on average 137 Bruchpilot proteins, many of which are arranged into clusters.

Nadine Ehmann
Sebastian van de Linde
Robert J. Kittel
ResearchOpen Access18 Aug 2014
Nature Communications

Volume: 5, P: 1-12
Serum Cortisol Levels of Well, Ill and Preterm Infants treated with Catecholamines < 30 Weeks of Gestational Age † 1528

Matthias Heckmann
Stefan A Wudy
Frank Pohlandt
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 261
Reference Range for Serum Cortisol Levels in Very Preterm Infants during the first two Weeks of Life 1529

Matthias Heckmann
Stefan A Wudy
Frank Pohlandt
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 261
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron–principal neuron synapse

Stefan Hefft
Peter Jonas
Research11 Sept 2005
Nature Neuroscience

Volume: 8, P: 1319-1328
A SUMO-dependent pathway controls elongating RNA Polymerase II upon UV-induced damage

Irina Heckmann
Maximilian J. Kern
Stefan Jentsch
ResearchOpen Access29 Nov 2019
Scientific Reports

Volume: 9, P: 1-10

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Alternative meiotic chromatid segregation in the holocentric plant Luzula elegans

Predicting enzyme turnover rates

Diversity favoured: heterozygosity attracts crossovers

The synaptonemal complex central element SCEP3 interlinks synapsis initiation and crossover formation in Arabidopsis thaliana

A haplotype-resolved pangenome of the barley wild relative Hordeum bulbosum

TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana

High level expression of glucocorticoid receptor (GR) is linked to aggressive tumor features, early biochemical recurrence, and genetic instability in prostate cancer

Changing local recombination patterns in Arabidopsis by CRISPR/Cas mediated chromosome engineering

Activity-dependent site-specific changes of glutamate receptor composition in vivo

Assessing Cortisol Production in Preterm Infants: Do Not Dispose of the Nappies

Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states

Serum Cortisol Levels of Well, Ill and Preterm Infants treated with Catecholamines < 30 Weeks of Gestational Age † 1528

Reference Range for Serum Cortisol Levels in Very Preterm Infants during the first two Weeks of Life 1529

Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron–principal neuron synapse

A SUMO-dependent pathway controls elongating RNA Polymerase II upon UV-induced damage

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