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  • Philip S. Lukeman and Stefan Howorka provide a training programme to improve the interdisciplinary breadth and depth of a nanoscience research group.

    • Philip S. Lukeman
    • Stefan Howorka
    Comments & Opinion
    Nature Nanotechnology
    Volume: 10, P: 992

  • Interest in oligonucleotide nanostructures has recently surged in basic and applied research. Here, the authors use native mass spectrometry and ion mobility to elucidate a prototypical hexameric DNA barrel structure as well as intermediates and byproducts of the assembly reaction.

    • Jeroen F. van Dyck
    • Jonathan R. Burns
    • Frank Sobott
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Artificial systems to control the transport of molecules across biomembranes can be useful for biosensing or drug delivery. Here, the authors assemble a DNA channel enabling the precisely timed, stimulus-controlled transport of functional proteins across bilayer membranes.

    • Swarup Dey
    • Adam Dorey
    • Hao Yan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • A modified nanopore enables enzyme-free threading of single polypeptides to detect post-translational modifications

    • Adam Dorey
    • Stefan Howorka
    News & Views
    Nature Nanotechnology
    Volume: 18, P: 1259-1260

  • Two studies describe progress in designing nanopores capable of detecting single protein molecules.

    • Stefan Howorka
    • Zuzanna S Siwy
    News & Views
    Nature Biotechnology
    Volume: 30, P: 506-507

  • Lipid bilayers form the thin and floppy membranes that define the boundary of compartments such as cells. Now, a method to control the shape and size of bilayers using DNA nanoscaffolds has been developed. Such designer materials advance synthetic biology and could find use in membrane research.

    • Stefan Howorka
    News & Views
    Nature Chemistry
    Volume: 9, P: 611-613

  • Nanopores have a wide range of applications in the field of sensing. Here the authors report on synthetic nanopores made of DNA and designed for the transit of folded proteins across membranes to allow for biosensing.

    • Tim Diederichs
    • Genevieve Pugh
    • Stefan Howorka
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Although DNA nanopores are widely explored as synthetic membrane proteins, it is still unclear how the anionic DNA assemblies stably reside within the hydrophobic core of a lipid bilayer. Here, the authors use molecular dynamics simulations to reveal the key dynamic interactions and energetics stabilizing the nanopore-membrane interaction.

    • Vishal Maingi
    • Jonathan R. Burns
    • Mark S. P. Sansom
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Nanopore label-free sequencing of DNA and RNA at the single-molecule level offers rapid readout, high accuracy, low cost and portability. This Review surveys technologies underpinning commercial and academic nanopore sequencing, and examines how underlying biochemical advances can fuel future developments in nanopore-based protein sequencing.

    • Adam Dorey
    • Stefan Howorka
    Reviews
    Nature Chemistry
    Volume: 16, P: 314-334

  • DNA nanotechnology enables the rational design of wide membrane nanopores for the direct and electrical single-molecule sensing of large proteins with hand-held analysis devices.

    • Yongzheng Xing
    • Adam Dorey
    • Stefan Howorka
    Research
    Nature Nanotechnology
    Volume: 17, P: 708-713

  • DNA nanopores can span lipid bilayers but how they interact with lipids is not known. Here the authors establish at single-molecule level the insertion mechanism and show that DNA nanopores can locally cluster and remodel membranes, and stabilize autonomously formed lipid nanotubes.

    • Oliver Birkholz
    • Jonathan R. Burns
    • Jacob Piehler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Building synthetic protocells and prototissues hinges on the formation of biomimetic skeletal frameworks. Here, the authors harness simplicity to create complexity by assembling DNA subunits into structural frameworks which support membrane-based protocells and prototissues.

    • Nishkantha Arulkumaran
    • Mervyn Singer
    • Jonathan R. Burns
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The COVID-19 pandemic has had a dramatic impact on the way we do research. Here, I share an approach to rebuild research capacity in a new collaborative fashion termed ‘teamlets’. Teamlets enable a team-based approach to boost morale, increase data integrity, faciliate interdisciplinarity and ensure continuity of expertise.

    • Stefan Howorka
    Comments & Opinion
    Nature Reviews Chemistry
    Volume: 6, P: 81-82

  • In a step toward nanopore sequencing of proteins, an aerolysin pore discriminates many of the proteinogenic amino acids.

    • Stefan Howorka
    • Zuzanna S. Siwy
    News & Views
    Nature Biotechnology
    Volume: 38, P: 159-160

  • Proteins, DNA and RNA can be used to build functional nanostructures. This Review compares protein and DNA/RNA in terms of biochemical properties and ease of engineering in three major areas of application: biomolecular recognition, biocatalysis and structural support.

    • Genevieve C. Pugh
    • Jonathan R. Burns
    • Stefan Howorka
    Reviews
    Nature Reviews Chemistry
    Volume: 2, P: 113-130

  • This Review examines the different building materials for membrane nanopores—proteins, peptides, synthetic organic molecules, and DNA—and explores the influence of the building material on pore structure, dynamics, function, and application.

    • Stefan Howorka
    Reviews
    Nature Nanotechnology
    Volume: 12, P: 619-630