Nurr1 is a promising therapeutic target for neurodegenerative diseases, but mechanistic understand of its modulation is limited and Nurr1 modulators as tools are lacking. Here, non-steroidal anti-inflammatory drugs are shown to act as inverse Nurr1 agonists, and their interactions with the NR4A family are characterised.
- Sabine Willems
- Whitney Kilu
- Daniel Merk
