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Showing 1–5 of 5 results
Advanced filters: Author: Stefan Nebl Clear advanced filters

  • Paul Pharoah, Joellen Schildkraut, Thomas Sellers and colleagues report a meta-analysis of genome-wide association studies for epithelial ovarian cancer and genotyping using the iCOGS array in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. They identify three new ovarian cancer susceptibility loci, including one specific to the serous subtype, and their integrated molecular analysis of genes and regulatory regions at these loci suggests disease mechanisms.

    • Paul D P Pharoah
    • Ya-Yu Tsai
    • Thomas A Sellers
    Research
    Nature Genetics
    Volume: 45, P: 362-370

  • Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arterial hypertension identifies 3 subgroups (endophenotypes) that improve risk stratification and provide new molecular insights.

    • Sokratis Kariotis
    • Emmanuel Jammeh
    • Richard C. Trembath
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

    • Josée Dupuis
    • Claudia Langenberg
    • Inês Barroso
    Research
    Nature Genetics
    Volume: 42, P: 105-116

  • Using a network propagation approach with integrated multi-omic data, Selevsek et al. develop a reproducible workflow for identifying drug toxicity effects in cellular systems. This is demonstrated with the analysis of anthracycline cardiotoxicity in cardiac microtissues under the effect of multiple drugs.

    • Nathalie Selevsek
    • Florian Caiment
    • Jos Kleinjans
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-15