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Showing 1–5 of 5 results
Advanced filters: Author: Stefania Crotta Clear advanced filters

  • Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.

    • Stefania Crotta
    • Matteo Villa
    • Andreas Wack
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.

    • Matteo Villa
    • Stefania Crotta
    • Andreas Wack
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Respiratory infections occur throughout life but how this shapes the lung immune system through time is unclear. Wack and colleagues show that a previous influenza infection recruits monocytes to the lung, which then assume an alveolar macrophage-like phenotype and mediate long-term antibacterial protection.

    • Helena Aegerter
    • Justina Kulikauskaite
    • Andreas Wack
    Research
    Nature Immunology
    Volume: 21, P: 145-157

  • Interferon αβ(IFNαβ) is known as a potent anti-viral factor, yet its role in influenza infection remains controversial. Here, the authors show that the IFNαβ response is a critical host factor, which, when excessive, causes strong inflammation and severe disease in a mouse model of acute influenza infection.

    • Sophia Davidson
    • Stefania Crotta
    • Andreas Wack
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-15