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Advanced filters: Author: Stefania Rapelli Clear advanced filters

DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells

DNMT3B-dependent DNA methylation provides epigenetic priming at epiblast stage by methylating enhancers of ectodermal genes to ensure proper differentiation toward mesoendoderm tissues.

Andrea Lauria
Guohua Meng
Salvatore Oliviero
ResearchOpen Access23 Jan 2023
Nature Communications

Volume: 14, P: 1-18
Metabolic control of DNA methylation in naive pluripotent cells

Stat3 depletion in pluripotent cells decreases α-ketoglutarate and increases the expression of Otx2 and its targets Dnmt3a and Dnmt3b, leading to global DNA hypermethylation.

Riccardo M. Betto
Linda Diamante
Graziano Martello
Research01 Feb 2021
Nature Genetics

Volume: 53, P: 215-229
Intragenic DNA methylation prevents spurious transcription initiation

Intragenic DNA methylation, dependent on Dnmt3b, protects the gene body from spurious entry of RNA Polymerase II and aberrant transcription initiation events.

Francesco Neri
Stefania Rapelli
Salvatore Oliviero
Research22 Feb 2017
Nature

Volume: 543, P: 72-77