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Showing 1–4 of 4 results
Advanced filters: Author: Stefano Gnan Clear advanced filters

  • Here, the authors show that common fragile sites are unstable under loose activation of the DNA-replication checkpoint. Tight checkpoint activation or CDK1 inhibition stabilizes them by advancing completion of their replication via extra replication-initiation events that are dependent on S-phase availability of proteins involved in pre-RC building.

    • Olivier Brison
    • Stefano Gnan
    • Michelle Debatisse
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 539-550

  • How nuclear architecture overall affects the replication-timing programme is not yet clear. Here the authors reveal RIF1’s dual role as a chromatin-interaction scaffold and regulator of replication timing that allows the coordination of these two aspects of nuclear function.

    • Stefano Gnan
    • Ilya M. Flyamer
    • Sara C. B. Buonomo
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Here the authors show that in activated B cells, RIF1 primarily binds early-replicating active chromatin and promotes early replication. RIF1 and MCM proteins establish early replication timing signatures genome-wide and ensure early replication of highly transcribed genes.

    • Daniel Malzl
    • Mihaela Peycheva
    • Rushad Pavri
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • A scalable approach to explore DNA replication in single cells reveals that although aneuploidy does not have a major impact on the pattern of replication, different cell types and sub-populations display distinguished replication paths.

    • Stefano Gnan
    • Joseph M. Josephides
    • Chun-Long Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15