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Showing 1–5 of 5 results
Advanced filters: Author: Stefano Mattarocci Clear advanced filters

  • In absence of telomerase, short telomeres trigger senescence. Here, the authors find using single-telomere-single-cell approaches in budding yeast, that one critically short telomere is required and sufficient to induce senescence. Some cells can escape via DNA rearrangements, trading stability for survival.

    • Prisca Berardi
    • Veronica Martinez-Fernandez
    • Maria Teresa Teixeira
    ResearchOpen Access
    Nature Communications
    P: 1-19

  • Chromosome ends must be protected from fusion by NHEJ despite Ku binding to telomeres. Here, the authors show that at telomeres yeast Rap1 inhibits Ku’s translocation on DNA, preventing NHEJ and protecting telomeres without displacing Ku.

    • Stefano Mattarocci
    • Sonia Baconnais
    • Stéphane Marcand
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Rif1 is involved in different processes such as telomere homeostasis, DNA replication timing, and DNA double strand break (DSB) repair pathway choice. Here, the authors reveal that Rif1 S-acylation facilitates the accumulation of Rif1 at DSBs, attenuation of DNA end-resection, and DSB repair by non-homologous end-joining.

    • Gabriele A. Fontana
    • Daniel Hess
    • Ulrich Rass
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Structure determination and functional analyses of budding yeast Rif1 reveal a novel, hooked N-terminal DNA-binding domain required for telomere maintenance and checkpoint control and show that Rif1's role in DNA-repair pathway choice is conserved in yeast and mammalian cells.

    • Stefano Mattarocci
    • Julia K Reinert
    • Ulrich Rass
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 588-595