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Tree cover gains in the moist tropics (1982–2015) were 56% naturally regenerated forests and 27% managed tree systems, with forest type influencing carbon recovery. Effective forest restoration requires robust tracking of forest types established by restoration efforts.

MSnLib is a large-scale, open MSⁿ spectral library featuring >2.3 million MSⁿ and >357,000 MS² spectra for 30,008 unique small molecules.

This Review establishes a roadmap to improve the sustainability of functional ceramics through a holistic approach that combines low-energy and low-CO₂ production methods, recycling strategies and supportive policy frameworks.

Individual molecules are now deterministically trapped in few-femtosecond laser pulses. This molecular conveyer belt may become a useful tool for probing ultrafast molecular dynamics.

By obtaining structural snapshots of the catalytic cycle of NADH:quinone oxidoreductase from Vibrio cholerae, the authors uncover its mechanism. They show how electrons are shuttled and determine the importance of the [2Fe-2S] cluster in the movement of the electron transfer switch.

Restoring forests is a policy priority globally, but often, little attention is paid to the type of forest being restored, which matters for biodiversity and livelihoods. Using a map of forest management types, this study assessed the extent of managed forests in recent tree-cover gains globally.

Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer.

Organismal ageing is driven by conserved biological processes. Here the authors build on a comparative RNA-seq analysis in three model organisms to demonstrate that the gene, bcat-1, which catalyses the degradation of branched-chain amino acids, regulates lifespan in worms.

To promote the recovery of the currently declining global trends in terrestrial biodiversity, increases in both the extent of land under conservation management and the sustainability of the global food system from farm to fork are required.

Multiomic factor analysis of blood multiomic data, including single-cell transcriptomics, for individuals with either acute or chronic coronary syndrome identifies immune cell signatures that correlate with treatment outcomes.

Two Co single crystal surfaces remain metallic up to 1 bar during Fischer-Tropsch synthesis. The observed intermediates support the carbide mechanism as the reaction pathway. By adding and removing CO we can follow the dynamics of the (dis)appearance of intermediates.

Reducing Emissions from Deforestation and forest Degradation (REDD) has been widely discussed as a way of mitigating climate change while concurrently benefitting biodiversity. This study combines a global land-use model and spatial data on species distributions to quantify the potential impacts of REDD in avoiding global species extinctions.

Nighttime lights from satellite are combined with a map of human settlements, showing that 19% of these areas, mainly in Africa, the Middle East and Asia, have no detectable artificial light. These data were then used in models to predict well-being.

Global spatial data for terrestrial vertebrate and vascular plant diversity, above- and below-ground biomass carbon, and potential clean freshwater volume are combined in a joint optimization study to identify potential synergies for conservation management.

Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, causing upregulation of defense mechanisms that promote longevity.

miR-132 was shown to drive pathological cardiac remodeling, a hallmark of heart failure. Here, the authors show that an antisense inhibitor of miR-132 has favourable pharmacokinetics, safety-tolerability and preclinical efficacy in mouse and porcine models of heart failure.

Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

Crystallographic ‘snapshots’ taken at intervals of femtoseconds to milliseconds after activation show how a light-activated sodium pump carries sodium ions across the cell membrane.

Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.

In this study, the authors generate a new mouse model that allows selective genetic targeting of microglial cells. Using this model, they show that elimination of TGF-β-activated kinase 1 (TAK1) specifically in microglial cells reduces pathology in a mouse model of multiple sclerosis by inhibiting NF-κB, ERK and JNK signaling pathways.

D-Glucosamine is a dietary supplement widely used for the treatment of osteoarthritis. Here Weimer et al. show that D-glucosamine extends the life span of Caenorhabditis elegans and of mice by mimicking the molecular effects of a diet low in carbohydrates.

Paired immunoglobulin-like receptors (PIRs) recognize β2-microglobulin. Munitz and colleagues show that PIR-A and PIR-B have opposing roles in eosinophil development in response to interleukin 5 in the bone marrow.

Microglia progenitors seed the central nervous system from the yolk sac, but little is known about the origin of non-parenchymal macrophages. Prinz and colleagues demonstrate that these macrophages in the central nervous system are related to but distinct from microglia and are largely of embryonic origin.

Integrating citizen science into artificial intelligence (AI) can help address major sustainability issues as well as some of the potential drawbacks associated with a wide use of AI. This Perspective highlights the advantages and challenges of such integration in light of achieving sustainable development.

Data from conventional sources cannot fully measure progress towards the Sustainable Development Goals (SDGs). Here the authors present a roadmap describing how citizen-science data can integrate traditional data and make a significant contribution in support of the SDGs agenda.

Felix Stickel and colleagues report the results of a genome-wide association study of alcohol-related cirrhosis. They confirm PNPLA3 as a susceptibility locus and identify new association signals in MBOAT7 and TM6SF2.