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Showing 1–10 of 10 results
Advanced filters: Author: Stella Lisova Clear advanced filters

  • Using resonance Raman spectroscopy and serial femtosecond X-ray crystallography, the authors show the heme a3 iron and CuB in the resting oxidized form of Cytochrome c Oxidase are coordinated by a hydroxide ion and a water molecule, respectively.

    • Izumi Ishigami
    • Raymond G. Sierra
    • Denis L. Rousseau
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Due to the pulsed nature of X-ray free electron laser (XFEL) instruments the majority of protein crystals, which are injected using continuous jet injection techniques are wasted. Here, the authors present a microfluidic device to deliver aqueous protein crystal laden droplets segmented with an immiscible oil and demonstrate that with this device an approx. 60% reduction in sample waste was achieved for data collection of 3-deoxy-D-manno-octulosonate 8-phosphate synthase crystals at the EuXFEL.

    • Austin Echelmeier
    • Jorvani Cruz Villarreal
    • Alexandra Ros
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • The European X-ray free-electron laser (EuXFEL) in Hamburg is the first XFEL with a megahertz repetition rate. Here the authors present the 2.9 Å structure of the large membrane protein complex Photosystem I from T. elongatus that was determined at the EuXFEL.

    • Chris Gisriel
    • Jesse Coe
    • Nadia A. Zatsepin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Here, the reaction of the suicide inhibitor sulbactam with the M. tuberculosis β-lactamase (BlaC) is investigated with time-resolved crystallography. Singular Value Decomposition is implemented to extract kinetic information despite changes in unit cell parameters during the time-course of the reaction.

    • Tek Narsingh Malla
    • Kara Zielinski
    • Marius Schmidt
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Small-molecule serial femtosecond X-ray crystallography (smSFX) characterizes microcrystals by indexing sparse serial XFEL diffraction frames, with little sample preparation, without beam damage, and at room temperature and pressure.

    • Elyse A. Schriber
    • Daniel W. Paley
    • J. Nathan Hohman
    ResearchOpen Access
    Nature
    Volume: 601, P: 360-365

  • Time-resolved serial femtosecond crystallography is used to reveal the structural changes that stabilize the charge-separation steps of electron-transfer reactions in the photosynthetic reaction centre of Blastochloris viridis on a timescale of picoseconds.

    • Robert Dods
    • Petra Båth
    • Richard Neutze
    Research
    Nature
    Volume: 589, P: 310-314

  • G protein-coupled receptors are a large family of signalling proteins that mediate cellular responses primarily via G proteins or arrestins, and they are targets of one-third of the current clinically used drugs; here, an active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin-1 is determined, revealing unique structural features that may constitute essential elements for arrestin-biased signalling.

    • Yanyong Kang
    • X. Edward Zhou
    • H. Eric Xu
    Research
    Nature
    Volume: 523, P: 561-567

  • Although the photocycle of the photosensory core module of the Stigmatella aurantiaca bacteriophytochrome 2 (SaBphP2) has been extensively studied, its early dynamics have not been fully resolved. Here, the authors use time-resolved serial femtosecond crystallography to probe the associated picosecond events and report on the relative population of Z and E isomers after light activation.

    • Tek Narsingh Malla
    • Luis Aldama
    • Marius Schmidt
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-10