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Showing 1–6 of 6 results
Advanced filters: Author: Stella Victorelli Clear advanced filters

  • Here the authors show that mitochondrial RNA leaks into the cytosol of senescent cells through sublethal apoptosis, driving inflammation. Blocking this pathway improves outcomes in Metabolic Dysfunction-Associated Steatohepatitis.

    • Stella Victorelli
    • Madeline Eppard
    • João F. Passos
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.

    • Stella Victorelli
    • Hanna Salmonowicz
    • João F. Passos
    ResearchOpen Access
    Nature
    Volume: 622, P: 627-636

  • There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer complex I (COPI) pathway is important for the survival of senescent cells, and suggests that targeting this pathway could hold therapeutic promise in the context of senescence-associated diseases.

    • Stella Victorelli
    • João F. Passos
    News & Views
    Nature Cell Biology
    Volume: 25, P: 1724-1725

  • SenNet Consortium members review current and emerging methodologies for spatially resolved mapping of senescent cells. They discuss their limitations and challenges involved in the aim of creating a comprehensive atlas of senescent cells during aging.

    • Aditi U. Gurkar
    • Akos A. Gerencser
    • João F. Passos
    Reviews
    Nature Aging
    Volume: 3, P: 776-790