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Showing 1–4 of 4 results
Advanced filters: Author: Stephan Uebel Clear advanced filters
  • Rare mutations in the high requirement temperature protein A1 (HTRA1) cause cerebral vasculopathy. Here, authors establish mechanistically distinct protein repair approaches to reverse the deleterious effects of pathogenic mutations interfering with the assembly and protease function of HTRA1.

    • Nathalie Beaufort
    • Linda Ingendahl
    • Martin Dichgans
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Artificial intelligence (AI) system is known to improve dermatologists’ diagnostic accuracy for melanoma. This group applies the eye-tracking technology on dermatologists when diagnosing dermoscopic images of melanomas and reports improved balanced diagnostic accuracy when using an X(explainable) AI system comparing to the standard one.

    • Tirtha Chanda
    • Sarah Haggenmueller
    • Titus J. Brinker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Proteins and peptides are amongst the most widely used research reagents but often their quality is inadequate and can result in poor data reproducibility. Here we propose a simple set of guidelines that, when correctly applied to protein reagents should provide more reliable experimental data.

    • Ario de Marco
    • Nick Berrow
    • Bertrand Raynal
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 12, P: 1-4
  • Prokaryotic condensins usually comprise an SMC homodimer, kleisin ScpA and ScpB. Structural and functional analyses of Bacillus subtilis condesin reveal an asymmetric bridge in which the termini of ScpA bind to distinct regions in each of the two SMC monomers. The findings suggest that the basic architecture for the tripartite condensin ring evolved before the emergence of eukaryotes.

    • Frank Bürmann
    • Ho-Chul Shin
    • Stephan Gruber
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 371-379