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Showing 1–2 of 2 results
Advanced filters: Author: Stephane Becart Clear advanced filters

  • The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.

    • Jae-Seung Moon
    • Shady Younis
    • William H. Robinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15