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Showing 1–3 of 3 results
Advanced filters: Author: Stephanie Dallaire Clear advanced filters

  • Last year the first map of single nucleotide changes was published; now an international consortium has mapped even larger areas of differences, called copy number variants. These variants are at least 1,000-base-pair differences between individual people, and have been linked to both benign and disease-causing changes in the human genome.

    • Richard Redon
    • Shumpei Ishikawa
    • Matthew E. Hurles
    Research
    Nature
    Volume: 444, P: 444-454

  • Mice lacking 4E-BP2, an eIF4E repressor, display increased translation of neuroligins; the mice also show autism-related behaviours and alterations in hippocampal synaptic activity, and these are reversed by normalization of eIF4E activity or neuroligin 1 levels.

    • Christos G. Gkogkas
    • Arkady Khoutorsky
    • Nahum Sonenberg
    Research
    Nature
    Volume: 493, P: 371-377