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Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans

Schreier et al. report a previously undescribed cytoplasmic condensate, termed the paternal epigenetic inheritance (PEI) granule, that contains the Argonaute protein WAGO-3 and 22G small RNAs and mediates paternal epigenetic inheritance in C. elegans.

Jan Schreier
Sabrina Dietz
René F. Ketting
Research07 Feb 2022
Nature Cell Biology

Volume: 24, P: 217-229
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Attitudes of relatives of mucopolysaccharidosis type III patients toward preconception expanded carrier screening

Stephanie C. M. Nijmeijer
Thirsa Conijn
Lotte Haverman
Research01 Jun 2020
European Journal of Human Genetics

Volume: 28, P: 1331-1340

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