Baumert, Maretti-Mira et al. integrate human epidemiological data and in vitro liver spheroid models to investigate PFHpA, an unregulated PFAS, in adolescent MASLD. Findings link PFHpA exposure to increased disease risk and identify key pathogenic mechanisms and potential therapeutic targets.
- Brittney O. Baumert
- Ana C. Maretti-Mira
- Lida Chatzi