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Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion

How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance and paradoxically even to its persistence.

Marilia Rita Pinzone
D. Jake VanBelzen
Una O’Doherty
ResearchOpen Access13 Feb 2019
Nature Communications

Volume: 10, P: 1-12
Success and failure of the cellular immune response against HIV-1

Understanding the success and failure of the HIV-specific cellular immune response has implications for immunotherapies and vaccines for HIV-1. Migueles and Connors discuss the mechanisms that are most likely responsible for durable and potent immunologic control of HIV-1 by the cellular immune response.

Stephen A Migueles
Mark Connors
Reviews19 May 2015
Nature Immunology

Volume: 16, P: 563-570
Broad HIV-1 neutralization mediated by CD4-binding site antibodies

Yuxing Li
Stephen A Migueles
John R Mascola
Research26 Aug 2007
Nature Medicine

Volume: 13, P: 1032-1034
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

A novel neutralizing antibody from a healthy HIV-1-infected donor that is specific for the membrane proximal region of gp41 is reported; the antibody has high potency and breadth, is not autoreactive and does not bind phospholipids.

Jinghe Huang
Gilad Ofek
Mark Connors
Research18 Sept 2012
Nature

Volume: 491, P: 406-412
HIV-specific CD8⁺ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

Stephen A. Migueles
Alisha C. Laborico
Mark Connors
Research07 Oct 2002
Nature Immunology

Volume: 3, P: 1061-1068
Clonal succession after prolonged antiretroviral therapy rejuvenates CD8⁺ T cell responses against HIV-1

Appay and colleagues show that long-term antiretroviral therapy is associated with clonal succession of HIV-1-specific CD8⁺ T cell populations, which evolved from an exhaustion-like toward a stemness-like phenotype.

Eoghann White
Laura Papagno
Victor Appay
Research23 Aug 2024
Nature Immunology

Volume: 25, P: 1555-1564
Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial

Results from a phase 1 clinical trial show that a broadly neutralizing, HIV-specific antibody is durably expressed in vivo from a viral vector, highlighting an alternate approach for the delivery of antibodies in humans.

Joseph P. Casazza
Evan M. Cale
Kathy Zephir
Research11 Apr 2022
Nature Medicine

Volume: 28, P: 1022-1030
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

Molecular and structural characterization is reported for a new broad and potent monoclonal antibody against HIV that binds to an epitope bridging the gp41 and gp120 subunits — the antibody affects a step in virus entry after binding to CD4 and before engagement of CCR5.

Jinghe Huang
Byong H. Kang
Mark Connors
Research03 Sept 2014
Nature

Volume: 515, P: 138-142
HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia

Moses et al. undertake a cross-sectional study on more than 1200 individuals living in Liberia with HIV and receiving antiretroviral therapy. They show that different antiviral treatment regimens and other factors effect virological failure rate and the prevalence of drug resistance.

James Soka Moses
Alice K. Pau
Stephen A. Migueles
ResearchOpen Access09 May 2025
Communications Medicine

Volume: 5, P: 1-10
Isolation of human monoclonal antibodies from peripheral blood B cells

Jinghe Huang
Nicole A Doria-Rose
Mark Connors
Protocols12 Sept 2013
Nature Protocols

Volume: 8, P: 1907-1915
MAdCAM costimulation through Integrin-α₄β₇ promotes HIV replication

Fatima Nawaz
Livia R. Goes
James Arthos
ResearchOpen Access06 Jun 2018
Mucosal Immunology

Volume: 11, P: 1342-1351

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