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Showing 1–6 of 6 results
Advanced filters: Author: Stephen C. Tovey Clear advanced filters

  • Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cells in JIA-uveitis and show that targeting B-T cell interactions suppresses disease in mouse models of uveitis.

    • Bethany R. Jebson
    • Benjamin Ingledow
    • Sarah Clarke
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • Defects in homologous recombination (HR) are found in some triple negative breast cancers, suggesting they may be sensitive to PARP inhibitors. In this phase II clinical trial of the PARP inhibitor rucaparib, changes in Ki67 levels did not correlate with markers of HR deficiency but HR deficiency was detected in 69% of tumours, indicating that PARP inhibitors may be a useful treatment.

    • Neha Chopra
    • Holly Tovey
    • Nicholas C. Turner
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • IP3 receptors mediate Ca2+ release from the endoplasmic reticulum. Here the authors show that only a small fraction of IP3 receptors initiate Ca2+ signals; these immobile IP3 receptors adjacent to the plasma membrane are optimally placed to control STIM1-dependent Ca2+ entry.

    • Nagendra Babu Thillaiappan
    • Alap P. Chavda
    • Colin W. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • H/D exchange reactions in the high vacuum of a mass spectrometer reveal how crown ethers move between ammonium ion binding sites of an oligolysine peptide. This study enables the dynamics of non-covalent interactions to be probed in a unique environment and could be applied to more complex artificial or natural systems.

    • Ana M Rossi
    • Andrew M Riley
    • Colin W Taylor
    Research
    Nature Chemical Biology
    Volume: 5, P: 631-639