The direction of integrin signalling is found to be determined by the coordinated and opposing binding waves of talin and Gα13 to the same region of the integrin β3 cytoplasmic domain at mutually exclusive but distinct sites, and a potent new anti-thrombotic drug that does not cause bleeding is designed on the basis of these findings.
- Bo Shen
- Xiaojuan Zhao
- Xiaoping Du
