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Showing 1–22 of 22 results
Advanced filters: Author: Stephen Holgate Clear advanced filters
  • Stephen Holgate argues for a return to more human-centred studies of allergy and asthma.

    • Stephen Holgate
    Comments & Opinion
    Nature
    Volume: 479, P: S22
  • Chronic fatigue syndrome (CFS) is a debilitating illness that affects many people. The aetiology and pathophysiology of CFS remain poorly understood, and few treatments are available.Nature Reviews Neuroscienceasked four scientists involved in CFS research about their views on the condition and the future of research — including the role of neuroscience — aimed at improving our understanding of this chronic illness.

    • Stephen T. Holgate
    • Anthony L. Komaroff
    • Simon Wessely
    Reviews
    Nature Reviews Neuroscience
    Volume: 12, P: 539-544
  • In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

    • Dinesh Aggarwal
    • Ben Warne
    • Ian G. Goodfellow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16
  • Asthma is a chronic inflammatory disease of the airways. Here, Holgate and colleagues outline the need for a better mechanistic understanding of the origins and heterogeneity of asthma, and discuss how this is leading a move towards more-personalized and targeted treatments.

    • Stephen T. Holgate
    • Sally Wenzel
    • Peter D. Sly
    Reviews
    Nature Reviews Disease Primers
    Volume: 1, P: 1-22
  • Allergen sensitization is triggered by activating receptors of the innate arm of the immune system. This leads to the recruitment and activation of dendritic cells, which have a sentinel role in orchestrating the attendant adaptive response. Stephen Holgate highlights recent findings on how innate receptors are triggered, cellular sources of cytokines driving immune cell activation and the identification of new helper T cell subsets driving chronic allergic airway inflammation.

    • Stephen T Holgate
    Reviews
    Nature Medicine
    Volume: 18, P: 673-683
  • Understanding the mechanisms of allergic inflammation is important for the improvement of current therapies and the development of novel therapies. This Review describes the current therapeutic strategies for allergy and asthma and highlights several innovative future strategies.

    • Stephen T. Holgate
    • Riccardo Polosa
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 218-230
  • Advancing drug development for airway diseases beyond the established mechanisms and symptomatic therapies requires redefining the classifications of airway diseases, considering systemic manifestations, developing new tools and encouraging collaborations.

    • Stephen Holgate
    • Alvar Agusti
    • Theodore F. Reiss
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 14, P: 367-368
  • Owing to their specificity, immunomodulatory biologics generally have better safety profiles than small-molecule drugs. However, adverse effects such as an increased risk of infections or cytokine release syndrome are of concern. Here, Park and colleagues discuss the current strategies used to predict and mitigate these adverse effects and consider how they can be used to inform the development of safer immunomodulatory biologics.

    • Jean G. Sathish
    • Swaminathan Sethu
    • B. Kevin Park
    Reviews
    Nature Reviews Drug Discovery
    Volume: 12, P: 306-324
  • Storing very large amounts of data and delivering them to researchers in an efficient, verifiable, and compliant manner, is one of the major challenges faced by health care providers and researchers in the life sciences. The electronic health record (EHR) at a hospital or clinic currently functions as a silo, and although EHRs contain rich and abundant information that could be used to understand, improve, and learn from care as part learning health system access to these data is difficult, and the technical, legal, ethical, and social barriers are significant. If we create a microservice ecosystem where data can be accessed through APIs, these challenges become easier to overcome: a service-driven design decouples data from clients. This decoupling provides flexibility: different users can write in their preferred language and use different clients depending on their needs. APIs can be written for iOS apps, web apps, or an R library, and this flexibility highlights the potential ecosystem-building power of APIs. In this article, we use two case studies to illustrate what it means to participate in and contribute to interconnected ecosystems that powers APIs in a healthcare systems.

    • Stephen K Woody
    • David Burdick
    • Erich S. Huang
    Comments & OpinionOpen Access
    npj Digital Medicine
    Volume: 3, P: 1-5