Nature Search

Virus crystallography comes of age

Stephen C. Harrison
News & Views07 Aug 1980
Nature

Volume: 286, P: 558-559
Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas
Balaji Virassamy
Sherene Loi
Amendments and Corrections22 Aug 2018
Nature Medicine

Volume: 24, P: 1941
Abrupt Southern Great Plains thunderstorm shifts linked to glacial climate variability

Thunderstorm activity in the Southern Great Plains was closely coupled to abrupt climate shifts during the last glacial period, according to an analysis of oxygen isotopes in modern rainfall and ancient speleothems from Texas.

Christopher R. Maupin
E. Brendan Roark
Judson W. Partin
Research06 May 2021
Nature Geoscience

Volume: 14, P: 396-401
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Genome-wide methylome sequencing of serial samples obtained from patients with acute myeloid leukemia reveals that epigenetic alleles and genetic alleles follow independent courses during disease evolution.

Sheng Li
Francine E Garrett-Bakelman
Christopher E Mason
Research20 Jun 2016
Nature Medicine

Volume: 22, P: 792-799
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

MEK inhibition in breast cancer is associated with increased tumour infiltrating lymphocytes (TILs), however, MAPK activity is required for T cells function. Here the authors show that TILs activity following MEK inhibition can be enhanced by agonist immunotherapy resulting in synergic therapeutic effects.

Sathana Dushyanthen
Zhi Ling Teo
Sherene Loi
ResearchOpen Access19 Sept 2017
Nature Communications

Volume: 8, P: 1-18
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Extensive, high-dimensional characterization of T cells in breast cancer reveals activated T_RM population and a gene signature associated with improved prognosis.

Peter Savas
Balaji Virassamy
Sherene Loi
Research25 Jun 2018
Nature Medicine

Volume: 24, P: 986-993
Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Zuzana Kos
Elvire Roblin
Zsuzsanna Bago-Horvath
ResearchOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-16
Sustained lymphocyte decreases after treatment for early breast cancer

Julia Dixon-Douglas
Balaji Virassamy
Sherene Loi
ResearchOpen Access21 Oct 2024
npj Breast Cancer

Volume: 10, P: 1-10
Tissue-resident memory T cells in breast cancer control and immunotherapy responses

T_RM cells have a role in peripheral immune surveillance in several organs. The presence of T_RM cells in the immune infiltrate is also associated with improved outcomes in patients with several solid tumour types, and these cells might have a role in the response to immune checkpoint inhibitors. In this Review, the authors describe the available date on the role of T_RM cells in patients with breast cancer

Ann Byrne
Peter Savas
Sherene Loi
Reviews28 Feb 2020
Nature Reviews Clinical Oncology

Volume: 17, P: 341-348
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Khalid El Bairi
Harry R. Haynes
Paul J. Van Diest
ReviewsOpen Access01 Dec 2021
npj Breast Cancer

Volume: 7, P: 1-17
Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer

Zhi Ling Teo
Mark J. O’Connor
Sherene Loi
ResearchOpen Access15 Aug 2023
npj Breast Cancer

Volume: 9, P: 1-16
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

The Hong Kong–Shanghai, Korean, Taiwan, US and International Kawasaki Disease Genetics Consortia report a genome-wide association study in Kawasaki disease. They identify a novel locus in the FCGR2A gene that confers elevated risk of disease.

Chiea Chuen Khor
Sonia Davila
Stephen Harrap
Research13 Nov 2011
Nature Genetics

Volume: 43, P: 1241-1246
Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

Kyaw Ze Ya Maung
Paul J. Leo
Thomas J Gonda
CorrespondenceOpen Access01 Jun 2018
Blood Cancer Journal

Volume: 8, P: 1-5
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Jan Hudeček
Leonie Voorwerk
Zsuzsanna Bago-Horvath
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-8
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Mohamed Amgad
Elisabeth Specht Stovgaard
Zaheed Husain
ReviewsOpen Access12 May 2020
npj Breast Cancer

Volume: 6, P: 1-13
Checkpoint blockade in the treatment of breast cancer: current status and future directions

Lironne Wein
Stephen J Luen
Sherene Loi
ReviewsOpen Access29 May 2018
British Journal of Cancer

Volume: 119, P: 4-11

Search

Virus crystallography comes of age

Publisher Correction: Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Abrupt Southern Great Plains thunderstorm shifts linked to glacial climate variability

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Sustained lymphocyte decreases after treatment for early breast cancer

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Combined PARP and WEE1 inhibition triggers anti-tumor immune response in BRCA1/2 wildtype triple-negative breast cancer

Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

Checkpoint blockade in the treatment of breast cancer: current status and future directions

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