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Showing 1–3 of 3 results
Advanced filters: Author: Stephen P. Chelko Clear advanced filters

  • Giardini et al. present an imaging method that combines quantitative measurements of cardiac electrophysiology with high-resolution three-dimensional structural reconstructions, enabling the detection of arrhythmogenic electrical coupling between cardiomyocytes and non-myocytes in murine hearts.

    • Francesco Giardini
    • Camilla Olianti
    • Leonardo Sacconi
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 4, P: 1466-1486

  • Cardiomyocyte cell cycle arrest is important for mammalian heart maturation, but the process is poorly understood. Here, the authors use exome sequencing to identify compound heterozygous ALMS1mutations associated with cardiomyocyte replication and provide evidence that Alström protein deficiency impairs postnatal cardiomyocyte cell cycle arrest.

    • Lincoln T. Shenje
    • Peter Andersen
    • Daniel P. Judge
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • The heart arises from distinct progenitor cells of both the first and second heart fields (FHF and SHF). Here, the authors generated precardiac organoids from mouse and human pluripotent cells and show that FHF and SHF cells form similarly to their in vivo counterparts in response to BMP and Wnt signalling, respectively.

    • Peter Andersen
    • Emmanouil Tampakakis
    • Chulan Kwon
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13