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Showing 1–2 of 2 results
Advanced filters: Author: Sterling C. Eckard Clear advanced filters

  • AhYoung, Eckard et al. show that the expression of Neutrophil Serine Protease 4 (NSP4) during the early stages of mast cell development regulates the levels of histamine and serotonin in mast cell granules. This study reveals an important physiological function of NSP4 in mast cell-mediated vascular leakage in mice, establishing NSP4 as a potential therapeutic target for mast cell-dependent immune disorders.

    • Andrew P. AhYoung
    • Sterling C. Eckard
    • Menno van Lookeren Campagne
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13

  • RIG-I-like receptors are activated by viral and other foreign RNAs. Stetson and colleagues show that the RNA exosome enzyme SKIV2L prevents RIG-I activation by endogenous RNAs generated by IRE-1 in stressed cells.

    • Sterling C Eckard
    • Gillian I Rice
    • Daniel B Stetson
    Research
    Nature Immunology
    Volume: 15, P: 839-845