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Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action

Thomas C. Leeper
Matthew B. Martin
Steven R. Van Doren
Research01 Apr 2002
Nature Structural Biology

Volume: 9, P: 397-403
Schizophrenia risk from complex variation of complement component 4

WebSchizophrenia is associated with genetic variation at the major histocompatibility complex locus; this study reveals that alleles at this locus associate with schizophrenia in proportion to their tendency to generate greater expression of complement component 4 (C4A) genes and that C4 promotes the elimination of synpases.

Aswin Sekar
Allison R. Bialas
Steven A. McCarroll
Research27 Jan 2016
Nature

Volume: 530, P: 177-183
Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12

Matrix metalloprotease-12 is secreted by macrophages during the inflammatory response, but was reported to be active near cell surfaces. Koppisetti et al.reveal the enzyme’s unprecedented use of two distinct surfaces to interact with lipid bilayers, thereby targeting it to cellular membranes.

Rama K. Koppisetti
Yan G. Fulcher
Steven R. Van Doren
Research21 Nov 2014
Nature Communications

Volume: 5, P: 1-14
Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants

In plants, light-dependent activation fatty acid synthesis (FAS) is mediated in part by acetyl-CoA carboxylase (ACCase). Here the authors identify a family of genes encoding carboxyltransferase interactors that attenuate FAS in the light by docking acetyl-CoA carboxylase to the plastid envelope.

Yajin Ye
Krisztina Nikovics
Jay J. Thelen
ResearchOpen Access03 Dec 2020
Nature Communications

Volume: 11, P: 1-14
Author Correction: Schizophrenia risk from complex variation of complement component 4

Aswin Sekar
Allison R. Bialas
Steven A. McCarroll
Amendments and Corrections15 Dec 2021
Nature

Volume: 601, P: E4-E5
Large multiallelic copy number variations in humans

Steven McCarroll and colleagues report an analysis of multiallelic copy number variants (mCNVs). They characterize mCNVs in 849 whole-genome sequences from the 1000 Genomes Project and find that mCNVs give rise to most gene dosage variation in humans.

Robert E Handsaker
Vanessa Van Doren
Steven A McCarroll
Research26 Jan 2015
Nature Genetics

Volume: 47, P: 296-303
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts

Jia Xu
Akella V. S. Sarma
Steven R. Van Doren
ResearchOpen Access13 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action

Schizophrenia risk from complex variation of complement component 4

Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12

Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants

Author Correction: Schizophrenia risk from complex variation of complement component 4

Large multiallelic copy number variations in humans

AI is a viable alternative to high throughput screening: a 318-target study

Multiple Ligand-Bound States of a Phosphohexomutase Revealed by Principal Component Analysis of NMR Peak Shifts

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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