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Showing 1–8 of 8 results
Advanced filters: Author: Steven Reiken Clear advanced filters

  • Ryanodine receptors type 2 (RyR2) are essential for cardiac muscle excitation-contraction coupling. Here, authors show that preferred conformations of RyR2 variants linked either to heart failure or inherited sudden cardiac death are similar, suggesting a common cause and potential treatment.

    • Marco C. Miotto
    • Steven Reiken
    • Andrew R. Marks
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Using electron cryomicroscopy, the closed-state structure of rabbit RyR1 is determined at 4.8 Å resolution; analysis confirms that the RyR1 architecture consists of a six-transmembrane ion channel with a cytosolic α-solenoid scaffold, and suggests a mechanism for Ca2+-induced channel opening.

    • Ran Zalk
    • Oliver B. Clarke
    • Andrew R. Marks
    Research
    Nature
    Volume: 517, P: 44-49

  • Ryanodine receptor type 1 (RyR1) are involved in skeletal muscle contraction. Here, the authors show that a transient calcium leak in response to exercise-induced post translational modifications of RyR1 causes mitochondrial remodeling to improve respiration.

    • Nadège Zanou
    • Haikel Dridi
    • Nicolas Place
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Increased calcium levels in dystrophic muscle have damaging consequences. In this report, Bellinger et al. show that nitrosylation of the ryanodine receptor calcium channel, leading to calcium leak through the channel, is an underlying cause of increased calcium levels in the muscle of dystrophic mdx mice. Treatment of the mice with a compound that inhibits calcium leak increases their muscle function and physical activity, pointing to a potential new treatment for muscular dystrophy (pages 243–244).

    • Andrew M Bellinger
    • Steven Reiken
    • Andrew R Marks
    Research
    Nature Medicine
    Volume: 15, P: 325-330