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Showing 1–3 of 3 results
Advanced filters: Author: Steven T. Staben Clear advanced filters

  • Discovery of macrocyclic ligands to the 19S regulatory particle protein PSMD2 enables the synthesis of heterobifunctional molecules that demonstrate proof-of-concept, targeted degradation of BRD4 through direct engagement of the 26S proteasome.

    • Charlene Bashore
    • Sumit Prakash
    • Erin C. Dueber
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 55-63

  • Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK with a similar efficacy to BAFF inhibition in two mouse models of SLE.

    • Hans D. Brightbill
    • Eric Suto
    • Nico Ghilardi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14