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The microRNA miR-71 suppresses maladaptive UPR^mt signaling through both cell-autonomous and cell-non-autonomous mechanisms

Mitochondria play roles in sensing environmental and physiological stress, but their response can become maladaptive during chronic stress. Here they identify a protective miRNA response in C. elegans that maintains tissue health by attenuating mitochondrial stress signaling.

Ina Kirmes
Grace Ching Ching Hung
Steven Zuryn
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 17, P: 1-16
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

Dai et al. show that the transcription factor ATFS-1 interferes with mitochondrial pre-initiation transcription complex assembly and promotes mitochondrial DNA repair, thereby reducing age-dependent mitochondrial DNA damage in Caenorhabditis elegans.

Chuan-Yang Dai
Chai Chee Ng
Steven Zuryn
Research17 Jul 2023
Nature Cell Biology

Volume: 25, P: 1111-1120
Publisher Correction: Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Arnaud Ahier
Chuan-Yang Dai
Steven Zuryn
Amendments and Corrections15 Feb 2018
Nature Cell Biology

Volume: 20, P: 361
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Saber H. Saber
Nyakuoy Yak
Merja Joensuu
ResearchOpen Access30 Sept 2025
Nature Metabolism

Volume: 7, P: 2117-2141
Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading

C. elegans miRNAs associate with AGO proteins ALG-1 and ALG-2. Here the authors provide a map of miRNAs loaded into ALG-1 and ALG-2 from intestine, body wall muscles and nervous system in C. elegans providing insights into spatial and temporal AGO loading flexibility.

Christopher A. Brosnan
Alexander J. Palmer
Steven Zuryn
ResearchOpen Access13 Apr 2021
Nature Communications

Volume: 12, P: 1-16
LONP-1 aids propagation of deleterious mtDNA

The integrity of the mitochondrial genome (mitochondrial DNA) is crucial for energy synthesis in all complex life. A study now reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that preferentially propagates genomes carrying deleterious mutations.

Ina Kirmes
Steven Zuryn
News & Views14 Feb 2022
Nature Cell Biology

Volume: 24, P: 127-128
Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Ahier et al. describe a method to isolate intact mitochondria from specific cells in Caenorhabditis elegans and show that the germline is more prone to propagating deleterious mitochondrial genomes than somatic lineages.

Arnaud Ahier
Chuan-Yang Dai
Steven Zuryn
Research22 Jan 2018
Nature Cell Biology

Volume: 20, P: 352-360
Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes.

Ayenachew Bezawork-Geleta
He Wen
Jiri Neuzil
ResearchOpen Access07 Jun 2018
Nature Communications

Volume: 9, P: 1-17
Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

UNC-89, a giant protein localized to muscle sarcomeres, contains 2 protein kinase domains, one of which, PK2 is a canonical kinase. A missense mutation expected to inactivate PK2 results in worms with an unexpected phenotype suggesting signaling from sarcomeres to mitochondria.

Yohei Matsunaga
Hiroshi Qadota
Guy M. Benian
ResearchOpen Access17 Oct 2024
Communications Biology

Volume: 7, P: 1-16

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The microRNA miR-71 suppresses maladaptive UPR^mt signaling through both cell-autonomous and cell-non-autonomous mechanisms

ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

Publisher Correction: Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function

Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading

LONP-1 aids propagation of deleterious mtDNA

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

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