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Showing 1–10 of 10 results
Advanced filters: Author: Stijn van Dongen Clear advanced filters

  • Clamp proteins that encircle DNA and then recruit enzymes are one of nature's ways of making catalysis on DNA processive. Here, a clamp protein is equipped with a synthetic catalyst that sequence-specifically oxidizes DNA. The resulting biohybrid catalyst shows processive behaviour, which is visualized by atomic force microscopy.

    • Stijn F. M. van Dongen
    • Joost Clerx
    • Roeland J. M. Nolte
    Research
    Nature Chemistry
    Volume: 5, P: 945-951

  • The algorithm Sylamer finds over- or underrepresented nucleotide motifs, such as microRNA seeds, in a gene list ranked according to expression levels and thus establishes whether a microRNA is directly affecting gene expression.

    • Stijn van Dongen
    • Cei Abreu-Goodger
    • Anton J Enright
    Research
    Nature Methods
    Volume: 5, P: 1023-1025

  • Karen Steel and colleagues report that the mouse diminuendo mutant, which shows progressive hearing loss, carries a mutation in the seed region of mouse miR-96. In an accompanying paper, Miguel Moreno-Pelayo and colleagues report similar mutations in the seed region of human miR-96 segregating with progressive hearing loss in two families.

    • Morag A Lewis
    • Elizabeth Quint
    • Karen P Steel
    Research
    Nature Genetics
    Volume: 41, P: 614-618

  • Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

    • Emily Stephenson
    • Gary Reynolds
    • Muzlifah Haniffa
    ResearchOpen Access
    Nature Medicine
    Volume: 27, P: 904-916

  • Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages.

    • Rasa Elmentaite
    • Natsuhiko Kumasaka
    • Sarah A. Teichmann
    ResearchOpen Access
    Nature
    Volume: 597, P: 250-255

  • This study provides a comprehensive spatiotemporal map of human and mouse gonadal differentiation, using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy, which can guide in vitro gonadogenesis.

    • Luz Garcia-Alonso
    • Valentina Lorenzi
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 607, P: 540-547

  • Single-cell and spatial transcriptomic profiling of the human endometrium highlights pathways governing the proliferative and secretory phases of the menstrual cycle. Analyses of endometrial organoids show that WNT and NOTCH signaling modulate differentiation into the secretory and ciliated epithelial lineages, respectively.

    • Luz Garcia-Alonso
    • Louis-François Handfield
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 1698-1711

  • Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. Here the authors perform single-cell omics analyses in CVID-discordant monozygotic twins and show epigenetic and transcriptional alterations associated with activation in memory B cells.

    • Javier Rodríguez-Ubreva
    • Anna Arutyunyan
    • Esteban Ballestar
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18