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Showing 1–2 of 2 results
Advanced filters: Author: Stuart Brabbs Clear advanced filters

  • NOD-like receptor family pyrin domain-containing 6 (NLRP6) reduces colitis severity in a gut microbiome-dependent manner; however, in the context of murine intestinal graft-versus-host disease, NLRP6 exacerbates symptoms independently of gut microbiome composition and diversity, with NLRP6-deficient animals displaying protection against disease.

    • Tomomi Toubai
    • Hideaki Fujiwara
    • Pavan Reddy
    Research
    Nature Microbiology
    Volume: 4, P: 800-812

  • The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.

    • Hideaki Fujiwara
    • Melissa D. Docampo
    • Pavan Reddy
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15