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Natural killer T cells: drivers or passengers in preventing human disease?

Natural killer T (NKT) cell defects have been implicated in several diseases such as autoimmunity, asthma and cancer, but will targeting them really be of clinical benefit? Here, the authors investigate this question and conclude that more careful studies are needed before the true clinical potential of NKT cell-targeted therapies can be determined.

Stuart P. Berzins
David S. Ritchie
Reviews08 Aug 2014
Nature Reviews Immunology

Volume: 14, P: 640-646
Retraction Note to: Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors

Yoshihiro Hayakawa
Stuart P Berzins
Mark J Smyth
Amendments and Corrections01 Aug 2006
Nature Immunology

Volume: 7, P: 890
Control points in NKT-cell development

Several diseases are associated with reduced numbers of natural killer T (NKT) cells. The authors of this Review ask what drives NKT-cell development in the thymus and what factors ensure NKT-cell survival, maturation and function in the periphery?

Dale I. Godfrey
Stuart P. Berzins
Reviews01 Jul 2007
Nature Reviews Immunology

Volume: 7, P: 505-518
NKT cells join the war on Lyme disease

Whether natural killer T cells recognize antigens derived from dangerous pathogens remains unclear. New data demonstrate that a glycolipid from Borrelia burgdorferi, the causative agent of Lyme disease, directly stimulates mouse and human natural killer T cells.

Dale I Godfrey
Stuart P Berzins
News & Views01 Sept 2006
Nature Immunology

Volume: 7, P: 904-906
Presumed guilty: natural killer T cell defects and human disease

There is currently a lack of consensus as to whether defects in natural killer T (NKT) cells contribute to human diseases. Here, the authors explain how contrasting results may have arisen and suggest more stringent methods to improve NKT cell analysis and therapeutic prospects.

Stuart P. Berzins
Mark J. Smyth
Alan G. Baxter
Reviews25 Jan 2011
Nature Reviews Immunology

Volume: 11, P: 131-142
Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors

Yoshihiro Hayakawa
Stuart P Berzins
Mark J Smyth
Research02 May 2004
Nature Immunology

Volume: 5, P: 590-596
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Godfrey, Pellicci and colleagues define the developmental stages and checkpoints for the development of mucosal-associated invariant T cells in humans and mice.

Hui-Fern Koay
Nicholas A Gherardin
Daniel G Pellicci
Research26 Sept 2016
Nature Immunology

Volume: 17, P: 1300-1311
Altered Populations of Unconventional T Cell Lineages in Patients with Langerhans Cell Histiocytosis

Jenée Mitchell
Egle Kvedaraite
George Kannourakis
ResearchOpen Access07 Nov 2018
Scientific Reports

Volume: 8, P: 1-13
Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells

Xuyen T. Dinh
Dragana Stanley
Margaret A. Jordan
ResearchOpen Access08 Dec 2021
Scientific Reports

Volume: 11, P: 1-23
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge

The authors compare the thymic development of several innate-like T cell populations, including natural killer T cells, mucosal-associated invariant T cells and γδ T cells. They focus on the cytokines, surface molecules and transcription factors that are necessary for the development of these cells and highlight some of the key differences from conventional T cell development.

Daniel G. Pellicci
Hui-Fern Koay
Stuart P. Berzins
Reviews24 Jun 2020
Nature Reviews Immunology

Volume: 20, P: 756-770

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