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Showing 1–3 of 3 results
Advanced filters: Author: Stuart Warriner Clear advanced filters

  • A discovery approach termed activity-directed synthesis is described; it exploits arrays of reactions whose outcome is critically dependent on the conditions used, and prioritizes reactions that yield bioactive product mixtures. The discovery of both bioactive small molecules and associated synthetic routes thus occurs in parallel.

    • George Karageorgis
    • Stuart Warriner
    • Adam Nelson
    Research
    Nature Chemistry
    Volume: 6, P: 872-876

  • Distinguishing between different proteins that each bind to the same type of glycan is challenging. Here, the authors demonstrate that an enzymatically synthesised library of Lewisx ‘glycofluoroforms’ that feature site-specific fluorination can discriminate closely related proteins.

    • Kristian Hollingsworth
    • Antonio Di Maio
    • Bruno Linclau
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Designer organelles could allow the isolation of synthetic biological pathways from endogenous components of the host cell. Here the authors engineer a peroxisomal protein import pathway orthogonal to the naturally occurring system.

    • Laura L. Cross
    • Rupesh Paudyal
    • Stuart L. Warriner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9