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Showing 1–3 of 3 results
Advanced filters: Author: Sudeepa Syamala Clear advanced filters

  • Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but have similar histological and clinical features. Here, the authors show that the epigenetic landscape of a range of NECs converges towards a common epigenetic state, while distinct subtypes occur within neuroendocrine prostate cancer contributing to intratumor heterogeneity in clinical samples.

    • Paloma Cejas
    • Yingtian Xie
    • Henry W. Long
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The role of MYC in transcriptional reprogramming in prostate cancer remains poorly characterized. Here, MYC overexpression antagonizes the canonical AR transcriptional program leading to prostate tumor initiation and progression by disrupting transcriptional pause release at AR-regulated genes.

    • Xintao Qiu
    • Nadia Boufaied
    • David P. Labbé
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17