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Showing 1–3 of 3 results
Advanced filters: Author: Sudheer Doss Clear advanced filters

  • External Control Arm methods for clinical trials were developed to compare the efficacy of a treatment to a control group that is built with data from external sources. Here, the authors present FedECA, a privacy-enhancing method for analyzing treatment effects across institutions, streamlining multi-centric trial design and thereby accelerating drug development while minimizing patient data exposure.

    • Jean Ogier du Terrail
    • Quentin Klopfenstein
    • Mathieu Andreux
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Standard approaches to identify the genetic changes that lead to disease are reversed by examination of genetic networks for perturbations that are associated with disease states, and following up candidate genes from there. This begins with three genes in mice that lead to obesity when mutated, demonstrating that complex genetic–environmental traits can be dissected with this new approach.

    • Yanqing Chen
    • Jun Zhu
    • Eric E. Schadt
    Research
    Nature
    Volume: 452, P: 429-435