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Showing 1–4 of 4 results
Advanced filters: Author: Sudhir Penugonda Clear advanced filters

  • Binding of virus, HIV-1, to cellular protein Siglec-1 is important for infection of immune cells. Here the authors show that a natural mutation leading to production of truncated Siglec-1 reduces HIV binding and infectivity transfer in vitro, but does not substantially affect infection or AIDS outcome in patients.

    • Javier Martinez-Picado
    • Paul J. McLaren
    • Amalio Telenti
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-7

  • Using a multi-OMICS approach, Haas et al identify 54 human genes and 16 host-targeting chemical compounds that regulate influenza A virus infection in lung epithelial cells, including AHNAK and COBP1 which are also essential for SARS-CoV-2 infection.

    • Kelsey M. Haas
    • Michael J. McGregor
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-27

  • By examining viral sequences in lymphoid tissue from three HIV-1-infected individuals receiving drug therapy, the authors find phylogenetic evidence for ongoing virus replication, suggesting that the antiretroviral drug concentration in the lymphoid tissue is insufficient to fully suppress the virus; using a mathematical model, they further explain why drug resistance does not necessarily arise as a result.

    • Ramon Lorenzo-Redondo
    • Helen R. Fryer
    • Steven M. Wolinsky
    Research
    Nature
    Volume: 530, P: 51-56