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Showing 1–8 of 8 results

Advanced filters: Author: Sue-Ann Mok Clear advanced filters

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.

Chao Wang
Li Fan
Li Gan
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-19
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

Mechanisms of cognitive resilience against Tau pathology are unknown. The authors show that inactivation of the microglial cGAS–interferon axis confers such resilience by preserving the neuronal expression of myocyte enhancer factor 2c.

Joe C. Udeochu
Sadaf Amin
Li Gan
ResearchOpen Access24 Apr 2023
Nature Neuroscience

Volume: 26, P: 737-750
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

Small heat shock proteins (sHSPs) limit the aggregation of proteins, such as tau. Here the authors show that Hsp27 recognizes two aggregation-prone regions of tau and that this interaction competes with Hsp27 oligomerization.

Rebecca Freilich
Miguel Betegon
Jason E. Gestwicki
ResearchOpen Access01 Nov 2018
Nature Communications

Volume: 9, P: 1-11
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation

The effects of chaperones on the aggregation of different tau variants are examined in a large-scale study. Among other findings, the work reveals that DnaJA2 can inhibit tau aggregation, a role that is supported by analysis of samples from human brains.

Sue-Ann Mok
Carlo Condello
Jason E. Gestwicki
Research30 Apr 2018
Nature Structural & Molecular Biology

Volume: 25, P: 384-393
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Acetylation of tau at K174 is identified in Alzheimer's disease (AD) brain tissue and exacerbates tau-mediated neurodegeneration and memory impairments in mice. Pharmacological inhibition of tau acetylation ameliorates these phenotypes in a mouse model of AD.

Sang-Won Min
Xu Chen
Li Gan
Research21 Sept 2015
Nature Medicine

Volume: 21, P: 1154-1162
Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer’s disease pathology

Pallabi Sil Paul
Tark Patel
Satyabrata Kar
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-16
Production of compartmented cultures of rat sympathetic neurons

Robert B Campenot
Karen Lund
Sue-Ann Mok
Protocols03 Dec 2009
Nature Protocols

Volume: 4, P: 1869-1887
A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures

Sue-Ann Mok
Karen Lund
Robert B Campenot
Research03 Feb 2009
Cell Research

Volume: 19, P: 546-560