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Showing 1–2 of 2 results
Advanced filters: Author: Sugyun An Clear advanced filters

  • Cancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associated with unfavourable prognosis in several cancer types.

    • Keun-Woo Lee
    • So-Young Yeo
    • Seok-Hyung Kim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-23

  • Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C bi-stably.

    • So-Young Yeo
    • Keun-Woo Lee
    • Seok-Hyung Kim
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16