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Showing 1–3 of 3 results
Advanced filters: Author: Suin Jo Clear advanced filters

  • mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.

    • Suin Jo
    • Lijin Li
    • Kenneth M. Murphy
    Research
    Nature
    P: 1-10

  • Some enhancers can limit their activities to specific spatial–temporal domains by enhancer suboptimization. Ou et al. find that classical dendritic cell (cDC) development depends on Irf8 suboptimization, which prevents unwanted IRF8 autoactivation in developing cDC2s while maximizing IRF8 expression in developed cDC1s.

    • Feiya Ou
    • Tian-Tian Liu
    • Kenneth M. Murphy
    Research
    Nature Immunology
    Volume: 25, P: 2043-2056

  • CD40 is typically understood as a costimulatory molecule. Here, the authors show CD4+ T cell-induced CD40 signaling in conventional type 1 dendritic cells results in complicated gene expression that can enhance CD8+ T cell priming by various underappreciated and independent mechanisms.

    • Renee Wu
    • Ray A. Ohara
    • Kenneth M. Murphy
    Research
    Nature Immunology
    Volume: 23, P: 1536-1550