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Showing 1–2 of 2 results
Advanced filters: Author: Sujay P. Sau Clear advanced filters

  • Droplet-based optical polymerase sorting employs a fluorescent sensor to monitor polymerase activity inside the microenvironment of uniform water-in-oil emulsions. Here, the authors use this technique to select and isolate single cells for evolution of an unnatural nucleic acid polymerase.

    • Andrew C. Larsen
    • Matthew R. Dunn
    • John C. Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.

    • Nicholas Chim
    • Changhua Shi
    • John C. Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11