Excess free fatty acids (FFAs) are known to induce insulin resistance, and a role for TLR4 has been implicated in this process. But FFAs are believed to be incapable of binding TLR4 directly. In a new study, Samir Bhattacharya and colleagues show that fetuin-A acts as an intermediary in this process by bindings FFAs and presenting them to TLR4. These results suggest fetuin-A as a new target to treat insulin resistance and diabetes.
- Durba Pal
- Suman Dasgupta
- Samir Bhattacharya
