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Showing 1–2 of 2 results
Advanced filters: Author: Sumirtha Balaratnam Clear advanced filters

  • The small modified nucleotide PreQ1 binds to the PreQ1 riboswitch and regulates gene expression by inducing RNA conformation change. Here the authors design and characterize a specific preQ1-derived probe by x-ray crystallography, mass spectral analysis and transcriptome-wide using Chem-CLIP.

    • Sumirtha Balaratnam
    • Curran Rhodes
    • John S. Schneekloth Jr
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-informed, fragment-based screening approach. This system was studied using high-resolution crystallography and applied to image RNA in cells.

    • Mo Yang
    • Peri R. Prestwood
    • John S. Schneekloth Jr
    Research
    Nature Chemistry
    Volume: 17, P: 1188-1195