Supersaturated amorphous drug–salt–polymer systems are known to improve the aqueous solubility of poorly water-soluble drugs as well as their bioavailability, however, the rational optimization of such systems is largely unexplored. Here, the authors optimize the polymer and salt combination for the drug celecoxib and achieve improved biopharmaceutical performance by experimental and computational characterization of their amorphous solid dispersions.
- Sumit Mukesh
- Goutam Mukherjee
- Rebecca C. Wade
