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Advanced filters: Author: Sumitabha Brahmachari Clear advanced filters

DNA supercoiling-mediated G4/R-loop formation tunes transcription by controlling the access of RNA polymerase

Here the authors by applying a single-molecule detection platform enabling FRET measurement on a long plasmid DNA construct, provide detailed insights on how negatively supercoiled DNA impacts co-transcriptional R-loop and G4 formation.

Jihee Hwang
Chun-Ying Lee
Sua Myong
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-14

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DNA supercoiling-mediated G4/R-loop formation tunes transcription by controlling the access of RNA polymerase

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