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Showing 1–3 of 3 results
Advanced filters: Author: Sundus F. Shalabi Clear advanced filters

  • Aging is the most important risk factor for breast cancer in women without genetic mutations. Shalabi and colleagues now show that histologically normal mammary epithelial cells genetically predisposed to cancer exhibit features of accelerated aging, such as the loss of cell lineage markers, differentiation defects and transcriptome-wide enrichment of expression of genes related to aging and inflammation.

    • Sundus F. Shalabi
    • Masaru Miyano
    • Mark A. LaBarge
    ResearchOpen Access
    Nature Aging
    Volume: 1, P: 838-849

  • Premalignant stromal cells from women with germline BRCA1 mutations exhibit increased expression of secreted factors regulating epithelial homeostasis in a paracrine fashion. These secreted factors, such as MMP3, promote premalignant epithelial changes including elevated proliferation and altered differentiation of a subpopulation of luminal progenitor cells.

    • Kevin Nee
    • Dennis Ma
    • Kai Kessenbrock
    Research
    Nature Genetics
    Volume: 55, P: 595-606