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Showing 1–5 of 5 results
Advanced filters: Author: Sung-Jan Lin Clear advanced filters

  • Glycogenin initiates glycogen synthesis, but its two human isoforms may do more than expected. Here, Weng et al. reveal that GYG2, despite low enzyme activity, drives glycogen particle assembly, uncovering a new layer of metabolic control.

    • Tzu-Han Weng
    • Yu-Chung Pien
    • Su-Yi Tsai
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • Pulmonary fibrosis is a major public health problem with unclear mechanism and limited therapeutic options. Here the authors show that a fibroblast-enriched endoplasmic reticulum protein, TXNDC5, promotes pulmonary fibrosis by stabilizing TGFBR1 and show the potential of TXNDC5 as a therapeutic target against pulmonary fibrosis.

    • Tzu-Han Lee
    • Chih-Fan Yeh
    • Kai-Chien Yang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-20

  • The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA double-strand break repair through the stimulation of RAD51-mediated homologous DNA pairing and strand exchange.

    • Chih-Ying Lee
    • Guan-Chin Su
    • Peter Chi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • In this Primer, Plikus and colleagues review the epidemiology, pathophysiology and diagnosis of androgenetic alopecia, an inherited hair loss condition that affects both men and women, and highlight the current and emerging treatment and management options.

    • Yingzi Liu
    • Antonella Tosti
    • Maksim V. Plikus
    Reviews
    Nature Reviews Disease Primers
    Volume: 11, P: 1-19