The two Na+ and water pore-forming claudins, claudin-2 and claudin-15, are reciprocally regulated during human development. This study shows that expression of these claudins is altered in celiac disease, graft-versus-host disease, and common variable immunodeficiency, but that the specific claudin affected differed between children and adults, suggesting distinct contributions to diarrheal pathophysiology.
- M. Lora D. M. Ong
- Sunil Yeruva
- Jerrold R. Turner
