Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory networks (GRNs) that connect transcription factors and signaling proteins to target genes. Here, the authors present single-cell Multi-Task Network Inference (scMTNI), a multi-task learning framework to infer cell type-specific GRN dynamics from scRNA-seq and scATAC-seq datasets collected for diverse cell fate specification trajectories.
- Shilu Zhang
- Saptarshi Pyne
- Sushmita Roy
