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Showing 1–2 of 2 results
Advanced filters: Author: Surabhi Kokane Clear advanced filters

  • Na+ /H+ exchangers regulate intracellular pH, sodium levels, and cell volume. Cryo-EM structures reveal lipid coordination at the dimer interfaces of NhaA with cardiolipin and endosomal NHE9 with PI(3,5)P2. These findings demonstrate how specific lipids can regulate ion-exchange activity by stabilizing dimerization with physiological ramifications.

    • Surabhi Kokane
    • Ashutosh Gulati
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Intracellular potassium (K+) homeostasis is achieved by activity of both ion channels and transporters. Here, the authors report structures of E. coli glutathione (GSH)-gated K+ efflux transporter KefC with bound K+ and conclude that the ion-binding site is adapted for binding a dehydrated ion.

    • Ashutosh Gulati
    • Surabhi Kokane
    • David Drew
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14